2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. MT-7716 hydrochloride

MT-7716 hydrochloride  (Synonyms: W-212393 hydrochloride)

Cat. No.: HY-107094 Purity: 99.06%
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MT-7716 hydrochloride (W-212393 hydrochloride) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention.

For research use only. We do not sell to patients.

MT-7716 hydrochloride Chemical Structure

MT-7716 hydrochloride Chemical Structure

CAS No. : 1215859-93-0

Size Price Stock Quantity
5 mg USD 530 In-stock
10 mg USD 900 In-stock
25 mg USD 1800 In-stock
50 mg USD 3060 In-stock
100 mg USD 5200 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of MT-7716 hydrochloride:

MT-7716 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

MT-7716 hydrochloride (W-212393 hydrochloride) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention[1].

IC50 & Target

NOP Receptor/ORL1

 

Molecular Weight

477.00

Formula

C27H29ClN4O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CNC(CN1C2=C(N(C3CCN([C@@H]4CC5=CC=CC6=C5C4=CC=C6)CC3)C1=O)C=CC=C2)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (419.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0964 mL 10.4822 mL 20.9644 mL
5 mM 0.4193 mL 2.0964 mL 4.1929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 5 mg/mL (10.48 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0964 mL 10.4822 mL 20.9644 mL 52.4109 mL
5 mM 0.4193 mL 2.0964 mL 4.1929 mL 10.4822 mL
10 mM 0.2096 mL 1.0482 mL 2.0964 mL 5.2411 mL
15 mM 0.1398 mL 0.6988 mL 1.3976 mL 3.4941 mL
20 mM 0.1048 mL 0.5241 mL 1.0482 mL 2.6205 mL
25 mM 0.0839 mL 0.4193 mL 0.8386 mL 2.0964 mL
30 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.7470 mL
40 mM 0.0524 mL 0.2621 mL 0.5241 mL 1.3103 mL
50 mM 0.0419 mL 0.2096 mL 0.4193 mL 1.0482 mL
60 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8735 mL
80 mM 0.0262 mL 0.1310 mL 0.2621 mL 0.6551 mL
100 mM 0.0210 mL 0.1048 mL 0.2096 mL 0.5241 mL
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MT-7716 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-77161215859-93-0W-212393MT7716MT 7716W212393W 212393Opioid ReceptorInhibitorinhibitorinhibit

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