MtInhA-IN-1

Cat. No.: HY-151941: FAQs
Data Sheet Handling Instructions

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MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC₅₀ of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM.

For research use only. We do not sell to patients.

MtInhA-IN-1 Chemical Structure

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Description

IC₅₀ & Target

IC50: 0.23 μM (Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA))^[1]
MIC: 0.4 μM (M. tuberculosis H37Rv strain), 0.1 μM (M. tuberculosis strains PT2), 0.2 μM (M. tuberculosis strains PT12), and 0.1 μM (M. tuberculosis strains PT20)^[1]

In Vitro

MtInhA-IN-1 (compound 19k) shows inhibitory activity against a panel of multidrug-resistant M. tuberculosis strains, M. tuberculosis strains PT2, PT12, and PT20. The MIC values of 0.1 μM, 0.2 μM, and 0.1 μM for PT2, PT12, and PT20, respectively. In addition, MtInhA-IN-1 has low cytotoxicity against HepG2 and Vero cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MtInhA-IN-1 (compound 19k; 300-450 μM/kg; p.o; daily; for 14 days) shows bacteriostatic effect in a murine model of tuberculosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	M. tuberculosis-infected mice ^[1]
Dosage:	300 μM/kg and 450 μM/kg
Administration:	Oral administration; daily; for 14 days
Result:	Reduced the growth of bacilli in the lungs of mice.

Molecular Weight

396.32

Formula

C₂₁H₂₂BrN₃

SMILES

CC1=NC2=C(C(NC3=CC=C(C=C3)N4CCCCC4)=C1)C=C(C=C2)Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Josiane Delgado Paz, et al. Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. [Content Brief]

MtInhA-IN-1 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MtInhA-IN-1BacterialMtInhA inhibitorMycobacterium tuberculosisorally active4-aminoquinolinesInhibitorinhibitorinhibit

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