2. Protein Tyrosine Kinase/RTK
  3. FLT3 PDGFR
  4. Multi-kinase inhibitor 4

Multi-kinase inhibitor 4 (compound 14) is an orally active inhibitor of FLT1, KDR, FLT3, FLT4, PDGFRα, PDGFRβ, with IC50s of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, 0.89 nM. Multi-kinase inhibitor 4 plays an important role in cancer research.

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Multi-kinase inhibitor 4 Chemical Structure

Multi-kinase inhibitor 4 Chemical Structure

CAS No. : 2648279-77-8

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Multi-kinase inhibitor 4 Related Antibodies

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Description

Multi-kinase inhibitor 4 (compound 14) is an orally active inhibitor of FLT1, KDR, FLT3, FLT4, PDGFRα, PDGFRβ, with IC50s of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, 0.89 nM. Multi-kinase inhibitor 4 plays an important role in cancer research[1].

IC50 & Target

PDGFRα

0.18 nM (IC50)

PDGFRβ

0.89 nM (IC50)

Molecular Weight

440.50

Formula

C25H24N6O2
CAS No.
SMILES

O=C(NC1=CC(C(C)(C)C)=NO1)CC(C=C2)=CC=C2N3C4=CC=C(C5=CNN=C5)C=C4N=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Multi-kinase inhibitor 4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase inhibitor 42648279-77-8FLT3PDGFRCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Platelet-derived growth factor receptorHuh7HepG2Hep3BHT29HCT116KATO III cell linesInhibitorinhibitorinhibit

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