2. Apoptosis NF-κB
  3. Survivin IAP NF-κB
  4. MX107

MX107 is a selective and potent survivin inhibitor that suppresses triple-negative breast cancer (TNBC) cell proliferation. MX107 induces degradation of survivin and inhibitor-of-apoptosis proteins (IAPs), which inhibits nuclear factor κB (NF-κB) activation induced by DNA damage. MX107 enhances tumoricidal efficacy of genotoxic treatments synergized with chemotherapeutic drugs.

For research use only. We do not sell to patients.

MX107 Chemical Structure

MX107 Chemical Structure

CAS No. : 2170102-50-6

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MX107 Related Antibodies

Top Publications Citing Use of Products

View All IAP Isoform Specific Products:

View All Isoforms
cIAP cIAP-1 cIAP-2 XIAP

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

MX107 is a selective and potent survivin inhibitor that suppresses triple-negative breast cancer (TNBC) cell proliferation. MX107 induces degradation of survivin and inhibitor-of-apoptosis proteins (IAPs), which inhibits nuclear factor κB (NF-κB) activation induced by DNA damage. MX107 enhances tumoricidal efficacy of genotoxic treatments synergized with chemotherapeutic drugs[1].

Molecular Weight

376.49

Formula

C24H28N2O2
CAS No.
SMILES

OC1=C2N=CC=CC2=C(COCC3=CC=C(CC)C=C3)C=C1CN4CCCC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MX107 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MX1072170102-50-6MX 107MX-107SurvivinIAPNF-κBNuclear factor-κBNuclear factor-kappaBsurvivinTNBCdegradationIAPsDNA damagetumoricidal efficacyInhibitorinhibitorinhibit

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