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  5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat  (Synonyms: MOG (35-55))

Cat. No.: HY-P1240 Purity: 99.97%
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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat has encephalitogenic activity and induces T?cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination.

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Chemical Structure

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Chemical Structure

CAS No. : 149635-73-4

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1 mg USD 70 In-stock
5 mg USD 190 In-stock
10 mg USD 305 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat:

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Related Antibodies

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Description

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat has encephalitogenic activity and induces T?cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination[1][2][3].

In Vitro

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 0-50 μg/mL; 72 h; lymph nodes cells) induces T?cell proliferative and secretes Th1 cytokines including IFN-γ, TNF-α, IL-10, IL-4 and IL-5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat increases the level of IgG[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Related Antibodies
In Vivo

Myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 is one of the targets of self-reactive T cell responses, leading to acute and later chronic autoimmune processes. MOG 35-55 is capable of inducing experimental autoimmune encephalomyelitis (EAE) in B6 mice[1].

Induction of experimental autoimmune encephalomyelitis (EAE) model[3]
Background
Myelin Oligodendrocyte Glycoprotein Peptide (35-55) CAN trigger an immune response against the CNS, and induces inflammation and destruction of myelin or antigen-bearing structures that causes neurological abnormalities.
Specific Mmodeling Methods
Mice: C57BL/6 background mice • 2–4 months old • male and female
Administration: On day 0: 3 mg/mL peptide plus CFA (4 mg/mL) • Mix thoroughly 1: 1 peptide and CFA solutions • s.c. • 100 μL for each hind flank; • On day 0 and day 2: 2.5 μg/mL of Bordetella pertussis toxin • i.p. • 200 μL
Note
1. Once peptide and CFA emulsion is formed, it can be stored at 4 °C for a few hours or used immediately.
2. Symptoms appear approximately 10–15 days after immunization.
3. When mice have clinical symptoms of EAE, hydrated food is placed on the cage floor to facilitate access to these mice.
4. Record parameters every other day at the beginning, and daily from 7th postimmunization day. Body weight decreases usually precedes EAE clinical signs and is a very objective and valuable measure.
Modeling Indicators
Evaluate changes in body weight and clinical scoring: body weight loss, loss of tail tonus, paralyzed tail, hind limb paraparesis, hind limb paralysis, front leg paralysis, tetraplegia, moribund, etc.
prototypical histopathological changes: Luxol fast blue staining of spinal cord for myelin evaluation shows infiltrates and demyelination in EAE animals.
Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808)
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HLA-DR2 (DRB1*1501) mice[1]
Dosage: 200 μg (0.2 mL)
Administration: Intraperitoneal injection; once, for 38 days
Result: Resulted in paralysis of both hind and forelimbs.
Molecular Weight

2581.95

Formula

C118H177N35O29S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (38.73 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3873 mL 1.9365 mL 3.8730 mL
5 mM 0.0775 mL 0.3873 mL 0.7746 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3873 mL 1.9365 mL 3.8730 mL 9.6826 mL
5 mM 0.0775 mL 0.3873 mL 0.7746 mL 1.9365 mL
10 mM 0.0387 mL 0.1937 mL 0.3873 mL 0.9683 mL
15 mM 0.0258 mL 0.1291 mL 0.2582 mL 0.6455 mL
20 mM 0.0194 mL 0.0968 mL 0.1937 mL 0.4841 mL
25 mM 0.0155 mL 0.0775 mL 0.1549 mL 0.3873 mL
30 mM 0.0129 mL 0.0646 mL 0.1291 mL 0.3228 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat149635-73-4MOG (35-55)OthersautoantigenicdemyelinatingplaqueautoimmunityInhibitorinhibitorinhibit

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