2. Apoptosis Metabolic Enzyme/Protease
  3. Caspase Ser/Thr Protease
  4. N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride

N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride  (Synonyms: TLCK hydrochloride)

Cat. No.: HY-137038
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N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible inhibitor for serine protease, which inhibits trypsin and trypsin-like protease by alkylating histidine residues in their active site. N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride inhibits caspase-3, caspase-6 and caspase-7, with IC50s of 12.0, 54.5 and 19.3 μM, respectively. N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in cell HL-60, and inhibits the decrease in mitochondrial transmembrane potential during apoptosis.

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N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride Chemical Structure

N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride Chemical Structure

CAS No. : 4238-41-9

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N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride Related Antibodies

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Description

N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible inhibitor for serine protease, which inhibits trypsin and trypsin-like protease by alkylating histidine residues in their active site. N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride inhibits caspase-3, caspase-6 and caspase-7, with IC50s of 12.0, 54.5 and 19.3 μM, respectively. N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in cell HL-60, and inhibits the decrease in mitochondrial transmembrane potential during apoptosis[1].

IC50 & Target

Caspase-3

12.0 μM (IC50)

Caspase-7

19.3 μM (IC50)

Caspase-6

54.5 μM (IC50)

Molecular Weight

369.31

Formula

C14H22Cl2N2O3S
CAS No.
SMILES

O=S(C1=CC=C(C)C=C1)(NC(C(CCl)=O)CCCCN)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-a-Tosyl-L-lysinyl-chloromethylketone4238-41-9TLCKCaspaseSer/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesHL-60irreversiblealkylationInhibitorinhibitorinhibit

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