2. PROTAC
  3. PROTAC Linkers
  4. N-Fmoc-8-aminooctanoic acid

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

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N-Fmoc-8-aminooctanoic acid Chemical Structure

N-Fmoc-8-aminooctanoic acid Chemical Structure

CAS No. : 126631-93-4

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Description

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Molecular Weight

381.46

Formula

C23H27NO4
CAS No.
Appearance

Solid

SMILES

OC(CCCCCCCNC(OCC1C2=CC=CC=C2C3=C1C=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
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N-Fmoc-8-aminooctanoic acid Related Classifications

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Keywords:

N-Fmoc-8-aminooctanoic acid126631-93-4PROTAC LinkersInhibitorinhibitorinhibit

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