2. PROTAC
  3. PROTAC Linkers
  4. N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl/ether and PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester Chemical Structure

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester Chemical Structure

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Based on 1 publication(s) in Google Scholar

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester Related Antibodies

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Description

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl/ether and PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

Alkyl/ether

 

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester Related Antibodies
Molecular Weight

807.76

Formula

C38H42F5N5O9
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCC[C@H](NC(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)=O)C(OC4=C(F)C(F)=C(F)C(F)=C4F)=O)CCOCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP esterPROTAC LinkersInhibitorinhibitorinhibit

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Product Name:
N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester
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HY-140847
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