2. PROTAC
  3. PROTAC Linkers
  4. N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5

N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 Chemical Structure

N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 Chemical Structure

CAS No. : 2107273-28-7

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N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 Related Antibodies

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 Related Antibodies
Molecular Weight

838.43

Formula

C45H60ClN3O10
CAS No.
Appearance

Solid

Color

Purple to dark purple

SMILES

CC1(C)C(/C=C/C=C/C=C2N(CCOCCOCCC(ON3C(CCC3=O)=O)=O)C(C=CC=C4)=C4C/2(C)C)=[N+](CCOCCOCCOCCOC)C5=CC=CC=C51.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

Methanol : 12.5 mg/mL (14.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1927 mL 5.9635 mL 11.9271 mL
5 mM 0.2385 mL 1.1927 mL 2.3854 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 1.1927 mL 5.9635 mL 11.9271 mL 29.8176 mL
5 mM 0.2385 mL 1.1927 mL 2.3854 mL 5.9635 mL
10 mM 0.1193 mL 0.5964 mL 1.1927 mL 2.9818 mL
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N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy52107273-28-7PROTAC LinkersInhibitorinhibitorinhibit

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Product Name:
N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5
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