2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N4-Acetylcytidine triphosphate sodium

N4-Acetylcytidine triphosphate sodium  (Synonyms: ac4CTP sodium)

Cat. No.: HY-111815A Purity: 99.43%
SDS COA Handling Instructions

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N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates.

For research use only. We do not sell to patients.

N4-Acetylcytidine triphosphate sodium Chemical Structure

N4-Acetylcytidine triphosphate sodium Chemical Structure

CAS No. : 2803886-33-9

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Based on 1 publication(s) in Google Scholar

Other Forms of N4-Acetylcytidine triphosphate sodium:

N4-Acetylcytidine triphosphate sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N4-Acetylcytidine triphosphate sodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates[1].

In Vitro

N4-Acetylcytidine triphosphate sodium (0.1-2 mM; 24-48 h) inhibits BV2 microglia cell grwoth[1].
? N4-Acetylcytidine triphosphate sodium (0.3-1 mM; 3-6 h) activates NFκB signaling and upregulates NLRP3 expression[1].
? N4-Acetylcytidine triphosphate sodium (0.3-1 mM; 3 h) increases the expression level of HMGB1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N4-Acetylcytidine triphosphate sodium Related Antibodies

Cell Viability Assay[1]

Cell Line: BV2 microglia
Concentration: 0.1-2 mM
Incubation Time: 24-48 hours
Result: Significantly inhibited BV2 microglia cell growth util cultured for 48 hours with a concentration of 0.3 mM.

Cell Viability Assay[1]

Cell Line: BV2 microglia
Concentration: 0.3 and 1 mM
Incubation Time: 3 and 6 hours
Result: Increased NLRP3 and NFκB expression at both mRNA and protein levels, activated the NFκB signaling.

Western Blot Analysis[1]

Cell Line: BV2 microglia
Concentration: 0.3 and 1 mM
Incubation Time: 3 hours
Result: Induced HMGB1 expression and it is necessary for NFkB signaling, NLRP3 expression and persistent HMGB1 expression.
Molecular Weight

613.12

Formula

C11H14N3Na4O15P3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O[C@@H]([C@H]([C@H](N1C(N=C(C=C1)NC(C)=O)=O)O2)O)[C@H]2COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
Structure Classification
Initial Source
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (163.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6310 mL 8.1550 mL 16.3100 mL
5 mM 0.3262 mL 1.6310 mL 3.2620 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (40.78 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.43%

SDS (252 KB)

COA (250 KB) HNMR (229 KB) RP-HPLC (242 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6310 mL 8.1550 mL 16.3100 mL 40.7751 mL
5 mM 0.3262 mL 1.6310 mL 3.2620 mL 8.1550 mL
10 mM 0.1631 mL 0.8155 mL 1.6310 mL 4.0775 mL
15 mM 0.1087 mL 0.5437 mL 1.0873 mL 2.7183 mL
20 mM 0.0816 mL 0.4078 mL 0.8155 mL 2.0388 mL
25 mM 0.0652 mL 0.3262 mL 0.6524 mL 1.6310 mL
30 mM 0.0544 mL 0.2718 mL 0.5437 mL 1.3592 mL
40 mM 0.0408 mL 0.2039 mL 0.4078 mL 1.0194 mL
50 mM 0.0326 mL 0.1631 mL 0.3262 mL 0.8155 mL
60 mM 0.0272 mL 0.1359 mL 0.2718 mL 0.6796 mL
80 mM 0.0204 mL 0.1019 mL 0.2039 mL 0.5097 mL
100 mM 0.0163 mL 0.0816 mL 0.1631 mL 0.4078 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N4-Acetylcytidine triphosphate sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N4-Acetylcytidine triphosphate2803886-33-9ac4CTPEndogenous MetabolitemetaboliteBV2 microgliaHMGB1inflamasomeInhibitorinhibitorinhibit

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