2. Others
  3. Isotope-Labeled Compounds
  4. NAD+-d4

NAD+-d4  (Synonyms: β-DPN-d4; β-NAD-d4; β-Nicotinamide Adenine Dinucleotide-d4)

Cat. No.: HY-W654288 Purity: 98.32%
COA Handling Instructions

Molarity Calculator

NAD+-d4 is the deuterium-labeled NAD+ (HY-B0445). NAD+-d4 is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

For research use only. We do not sell to patients.

NAD+-d<sub>4</sub> Chemical Structure

NAD+-d4 Chemical Structure

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500 μg USD 745 In-stock

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Based on 1 publication(s) in Google Scholar

Other Forms of NAD+-d4:

NAD+-d4 Related Antibodies

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Description

NAD+-d4 is the deuterium-labeled NAD+ (HY-B0445). NAD+-d4 is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAD+-d4 Related Antibodies
Molecular Weight

667.45

Formula

C21H23D4N7O14P2
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H]([N+]2=C([2H])C([2H])=C([2H])C(C(N)=O)=C2[2H])O[C@@H]1COP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4)O3)(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 41.67 mg/mL (62.43 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4982 mL 7.4912 mL 14.9824 mL
5 mM 0.2996 mL 1.4982 mL 2.9965 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.71%

COA (261 KB) Elemental Analysis Report (120 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4982 mL 7.4912 mL 14.9824 mL 37.4560 mL
5 mM 0.2996 mL 1.4982 mL 2.9965 mL 7.4912 mL
10 mM 0.1498 mL 0.7491 mL 1.4982 mL 3.7456 mL
15 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4971 mL
20 mM 0.0749 mL 0.3746 mL 0.7491 mL 1.8728 mL
25 mM 0.0599 mL 0.2996 mL 0.5993 mL 1.4982 mL
30 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2485 mL
40 mM 0.0375 mL 0.1873 mL 0.3746 mL 0.9364 mL
50 mM 0.0300 mL 0.1498 mL 0.2996 mL 0.7491 mL
60 mM 0.0250 mL 0.1249 mL 0.2497 mL 0.6243 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NAD+-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAD+-d4β-DPN-d4 β-NAD-d4 β-Nicotinamide Adenine Dinucleotide-d4Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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