NAD⁺-¹³C₅ (Synonyms: β-DPN-¹³C₅; β-NAD-¹³C₅; β-Nicotinamide Adenine Dinucleotide-¹³C₅)

Cat. No.: HY-B0445S1 Purity: 98.90%: FAQs
Data Sheet SDS COA Handling Instructions

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NAD+-¹³C₅-1 is the ¹³C labeled NAD+[1]. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

For research use only. We do not sell to patients.

NAD<sup>+</sup>-<sup>13</sup>C<sub>5</sub> Chemical Structure

NAD⁺-¹³C₅ Chemical Structure

CAS No. : 1859096-06-2

Size	Price	Stock	Quantity
1 mg	USD 6100	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of NAD⁺-¹³C₅:

NAD+ In-stock
NAD+-d₄ Get quote
NAD⁺-¹³C₅ ammonium Get quote

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Description

NAD+-¹³C₅-1 is the ¹³C labeled NAD+[1]. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

668.39

Formula

C₁₆¹³C₅H₂₇N₇O₁₄P₂

CAS No.

1859096-06-2

Unlabeled CAS

53-84-9

Appearance

Solid

Color

White to off-white

SMILES

O[13C@H]1[13C@@H](O)[13C@H]([N+]2=CC=CC(C(N)=O)=C2)O[13C@@H]1[13CH2]OP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4)O3)(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 41.67 mg/mL (62.34 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4961 mL	7.4807 mL	14.9613 mL
5 mM	0.2992 mL	1.4961 mL	2.9923 mL
10 mM	0.1496 mL	0.7481 mL	1.4961 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.90%

Select Batch:

Data Sheet (283 KB) SDS (252 KB)

COA (264 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Viollet, B., et al., Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond), 2012. 122(6): p. 253-70. [Content Brief]

[3]. Brandt, U., Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem, 2006. 75: p. 69-92. [Content Brief]

[4]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4961 mL	7.4807 mL	14.9613 mL	37.4033 mL
	5 mM	0.2992 mL	1.4961 mL	2.9923 mL	7.4807 mL
	10 mM	0.1496 mL	0.7481 mL	1.4961 mL	3.7403 mL
	15 mM	0.0997 mL	0.4987 mL	0.9974 mL	2.4936 mL
	20 mM	0.0748 mL	0.3740 mL	0.7481 mL	1.8702 mL
	25 mM	0.0598 mL	0.2992 mL	0.5985 mL	1.4961 mL
	30 mM	0.0499 mL	0.2494 mL	0.4987 mL	1.2468 mL
	40 mM	0.0374 mL	0.1870 mL	0.3740 mL	0.9351 mL
	50 mM	0.0299 mL	0.1496 mL	0.2992 mL	0.7481 mL
	60 mM	0.0249 mL	0.1247 mL	0.2494 mL	0.6234 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

NAD⁺-¹³C₅ Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAD⁺-¹³C₅1859096-06-2β-DPN-¹³C₅ β-NAD-¹³C₅ β-Nicotinamide Adenine Dinucleotide-¹³C₅Endogenous MetaboliteInhibitorinhibitorinhibit

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NAD+-13C5 (Synonyms: β-DPN-13C5; β-NAD-13C5; β-Nicotinamide Adenine Dinucleotide-13C5)

Other Forms of NAD+-13C5:

NAD+-13C5 Related Antibodies

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Biological Activity

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References

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NAD+-13C5 Related Antibodies

Molarity Calculator

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Complete Stock Solution Preparation Table

NAD+-13C5 Related Classifications