Nafcillin sodium

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Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections.

For research use only. We do not sell to patients.

Nafcillin sodium Chemical Structure

CAS No. : 985-16-0

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Other In-stock Forms of Nafcillin sodium:

Nafcillin sodium monohydrate

Other Forms of Nafcillin sodium:

2 Publications Citing Use of MCE Nafcillin sodium

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections^[1]^[2].

IC₅₀ & Target

β-lactam

In Vivo

Nafcillin sodium (100 mg/kg; s.c.) exhibits bactericidal activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), with MICs of 0.5 μg/mL and 64.0 μg/mL for S. aureus strains Xen-29 and Xen-1, respectively, in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD-1 female mice (20-25 g), with MRSA- and MSSA-infected^[3]
Dosage:	100 mg/kg
Administration:	Subcutaneous injection
Result:	Protected 100% of the healthy mice with MSSA infections.

Clinical Trial

Molecular Weight

436.46

Formula

C₂₁H₂₁N₂NaO₅S

CAS No.

985-16-0

SMILES

O=C([C@@H]1N(C2=O)[C@]([C@@H]2NC(C(C3=CC=CC=C3C=C4)=C4OCC)=O)([H])SC1(C)C)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tan AK, et, al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):191-6. [Content Brief]

[2]. Palmer DL, et, al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg. 1995 Mar;59(3):626-31. [Content Brief]

[3]. Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51(5): 1787-1794. [Content Brief]