Nasunin  (Synonyms: Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside)

Nasunin, an antioxidant anthocyanin, possesses antiangiogenic activity^[1].

Nasunin at higher 10 µM suppresses microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring^[1].
Nasunin suppresses HUVEC proliferation in a dose-dependent manner (50-200 µM)^[1].
Nasunin diminishes LPS-induced nuclear factor-κB (NF-κB) activation by suppressing the degradation of inhibitor of κB-α and nuclear translocation of p65 subunit of NF-κB. Nasunin also attenuates the phosphorylation of Akt and p38, signaling molecules involved in pro-inflammatory mediator production^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

955.26

C₄₂H₄₇ClO₂₃

28463-30-1

Solid

White to off-white

O[C@H]([C@@H]([C@H]([C@@H](O1)C)OC(/C=C/C2=CC=C(C=C2)O)=O)O)[C@@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC4=CC(C(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=CC(O)=C6)=C6[O+]=C4C7=CC(O)=C(C(O)=C7)O.[Cl-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Kiminori Matsubara, et al. Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels. J Agric Food Chem. 2005 Aug 10;53(16):6272-5.  [Content Brief]

  [2]. Wataru Komatsu, et al. Nasunin inhibits the lipopolysaccharide-induced pro-inflammatory mediator production in RAW264 mouse macrophages by suppressing ROS-mediated activation of PI3 K/Akt/NF-κB and p38 signaling pathways. Biosci Biotechnol Biochem. 2017 O  [Content Brief]