Navitoclax dihydrochloride (Synonyms: ABT-263 dihydrochloride)

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Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a K_i value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research.

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Navitoclax dihydrochloride Chemical Structure

CAS No. : 1093851-28-5

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101 Publications Citing Use of MCE Navitoclax dihydrochloride

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: Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Sep 6;43(1):253. [Abstract]; The co-treatment with ABT-263 (Navitoclax) (0.2 μM) and KRIBB-11 inhibits the cell viability in iCCA hCAFs. Effect of ABT-263, KRIBB-11, and their co-administration on the viability of iCCA hCAFs, grown for 72 h in culture medium supplemented with 10% FBS. Note the higher anti-growth effects of the two combined drugs than single treatments.

: Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 Oct 6;8(1):102. [Abstract]; Cell viability of the captured clones in response to ABT263 (Navitoclax) (2 days). Results are representative of two independent experiments with three technical replicates per experiment, and error bars represent SEM.

: Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6803. [Abstract]; Navitoclax (0.5-1.5 μM;10 d) combined with decitabine significantly reduces the transcriptional activity of KIAA1522-a6 in siPTBP1-transfected A2780 cells.

: Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Sep 24;9(10):986. [Abstract]; Cells are treated with 25 nM siRNA for 48 hours followed by 1 μM ABT-263 for 36 hours.

: Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Med Chem Lett. 2015 Jun 22;6(8):948-52. [Abstract]; Combination treatment. (a) Comparison of AZD-8055 and ABT-263 treatment in all cell lines. Red indicates sensitivity, while blue indicates resistance. (b) Depiction of synergism where the values shown are excess over Bliss Independence, a prediction of inhibition without synergism. Increased synergism is evident by an increased number, shown in red, while negative numbers in blue represent an antagonistic effect.

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Description	Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a K_i value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research^[1].
Molecular Weight	1047.53
Formula	C₄₇H₅₇Cl₃F₃N₅O₆S₃
CAS No.	1093851-28-5
SMILES	O=C(C1=CC=C(N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(Cl)C=C4)C=C1)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)=O.Cl.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Lock R, et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50(6):1181-9. [Content Brief]

Navitoclax dihydrochloride Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Navitoclax1093851-28-5ABT-263ABT263ABT 263Bcl-2 FamilyInhibitorinhibitorinhibit

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Navitoclax dihydrochloride (Synonyms: ABT-263 dihydrochloride)

Other Forms of Navitoclax dihydrochloride:

Navitoclax dihydrochloride Related Antibodies

101 Publications Citing Use of MCE Navitoclax dihydrochloride

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Bcl-2 Family Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Navitoclax dihydrochloride Related Classifications

Molarity Calculator

Dilution Calculator