2. Apoptosis
  3. Bcl-2 Family
  4. Navitoclax dihydrochloride

Navitoclax dihydrochloride  (Synonyms: ABT-263 dihydrochloride)

Cat. No.: HY-10087A1
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Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research.

For research use only. We do not sell to patients.

Navitoclax dihydrochloride Chemical Structure

Navitoclax dihydrochloride Chemical Structure

CAS No. : 1093851-28-5

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Navitoclax dihydrochloride Related Antibodies

Top Publications Citing Use of Products

87 Publications Citing Use of MCE Navitoclax dihydrochloride

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    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Sep 24;9(10):986.  [Abstract]

    Cells are treated with 25 nM siRNA for 48 hours followed by 1 μM ABT-263 for 36 hours.

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Med Chem Lett. 2015 Jun 22;6(8):948-52.  [Abstract]

    Combination treatment. (a) Comparison of AZD-8055 and ABT-263 treatment in all cell lines. Red indicates sensitivity, while blue indicates resistance. (b) Depiction of synergism where the values shown are excess over Bliss Independence, a prediction of inhibition without synergism. Increased synergism is evident by an increased number, shown in red, while negative numbers in blue represent an antagonistic effect.

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    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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    Description

    Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research[1].

    Molecular Weight

    1047.53

    Formula

    C47H57Cl3F3N5O6S3
    CAS No.
    SMILES

    O=C(C1=CC=C(N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(Cl)C=C4)C=C1)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)=O.Cl.Cl
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    Navitoclax dihydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Navitoclax1093851-28-5ABT-263ABT263ABT 263Bcl-2 FamilyInhibitorinhibitorinhibit

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