1. Others Apoptosis Metabolic Enzyme/Protease
  2. Isotope-Labeled Compounds MDM-2/p53 E1/E2/E3 Enzyme
  3. Navtemadlin-d7

Navtemadlin-d7  (Synonyms: AMG 232-d7; KRT-232-d7)

Cat. No.: HY-12296S
Handling Instructions

Navtemadlin-d7 is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].

For research use only. We do not sell to patients.

Navtemadlin-d<sub>7</sub> Chemical Structure

Navtemadlin-d7 Chemical Structure

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Description

Navtemadlin-d7 is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

575.60

Formula

C28H28D7Cl2NO5S

Unlabeled CAS

1352066-68-2

SMILES

O=C(O)C[C@]1(C)C(N([C@H](CS(=O)(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C(C)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Navtemadlin-d7
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HY-12296S
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