2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. NCFP

NCFP is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM). NCFP can be used in the study of central nervous system diseases.

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NCFP Chemical Structure

NCFP Chemical Structure

CAS No. : 774548-65-1

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NCFP Related Antibodies

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Description

NCFP is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM). NCFP can be used in the study of central nervous system diseases[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
214 nM
Compound: 163; NCFP
Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells assessed as increase in calcium mobilization after 60 secs in presence of glutamate by Fluo-4 AM dye-based fluorescence assay
Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells assessed as increase in calcium mobilization after 60 secs in presence of glutamate by Fluo-4 AM dye-based fluorescence assay
[PMID: 29939744]
Molecular Weight

409.80

Formula

C21H13ClFN3O3
CAS No.
SMILES

O=C(C1=NC=CC=C1)NC2=CC=C(Cl)C=C2CN(C(C3=C4C=CC=C3F)=O)C4=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NCFP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCFP774548-65-1mGluRMetabotropic glutamate receptorsmGlu5PAMmodulatorCNSInhibitorinhibitorinhibit

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