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Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups.

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Nefopam Chemical Structure

Nefopam Chemical Structure

CAS No. : 13669-70-0

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Nefopam Related Antibodies

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Description

Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups[1][2][3].

In Vitro

Nefopam (0.1-100 μM; 15 min) inhibits the uptake of 22Na in a concentration-dependent manner in SK-N-SH cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nefopam Related Antibodies

Cell Viability Assay[1]

Cell Line: SK-N-SH cells
Concentration: 0.1-100 µM
Incubation Time: 15 min (preincubate)
Result: Inhibited the uptake of 22Na with an IC50 value of 27 µM.
In Vivo

Nefopam (0-10 mg/kg; i.v.; single) protects mice against electroshock induced seizures[1]. Nefopam (10, 30, 60 mg/kg; i.p.; single) shows a dose-dependent attenuation of mechanical allodynia and decreased neurokinin-1 receptor concentration in vincristine-induced peripheral neuropathy model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male NMRI mice (25-30 g; 6 to7-week-old; electroshock-induced seizures model)[1]
Dosage: 0-10 mg/kg
Administration: Intravenous injection; single
Result: Produced dose-dependent protection against maximal electroshock seizures in mice with an ED50 of 3.8 (2.9-5.1) mg/kg.
Animal Model: Adult male mice (10-week-old; 25-30 g; vincristine-induced peripheral neuropathy model)[2].
Dosage: 10, 30, 60 mg/kg
Administration: Intraperitoneal injection; single
Result: Significantly decreased the percentage of NK1 receptors in the spinal cord at dosage of 60 mg/kg.
Showed a sustained increase in paw withdrawal threshold against mechanical stimuli.
Molecular Weight

253.34

Formula

C17H19NO
CAS No.
SMILES

CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1
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Purity & Documentation
References
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Nefopam Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nefopam13669-70-0FenazoxineOthersneuropathic painpostoperative shiveringpostoperative hiccupsanticonvulsantSK-N-SHInhibitorinhibitorinhibit

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