Nefopam (Synonyms: Fenazoxine)

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Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC₅₀=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups.

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Nefopam Chemical Structure

CAS No. : 13669-70-0

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Other In-stock Forms of Nefopam:

Nefopam hydrochloride

Other Forms of Nefopam:

Nefopam hydrochloride In-stock

2 Publications Citing Use of MCE Nefopam

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Description

In Vitro

Nefopam (0.1-100 μM; 15 min) inhibits the uptake of ²²Na in a concentration-dependent manner in SK-N-SH cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SK-N-SH cells
Concentration:	0.1-100 µM
Incubation Time:	15 min (preincubate)
Result:	Inhibited the uptake of ²²Na with an IC₅₀ value of 27 µM.

In Vivo

Nefopam (0-10 mg/kg; i.v.; single) protects mice against electroshock induced seizures^[1]. Nefopam (10, 30, 60 mg/kg; i.p.; single) shows a dose-dependent attenuation of mechanical allodynia and decreased neurokinin-1 receptor concentration in vincristine-induced peripheral neuropathy model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male NMRI mice (25-30 g; 6 to7-week-old; electroshock-induced seizures model)^[1]
Dosage:	0-10 mg/kg
Administration:	Intravenous injection; single
Result:	Produced dose-dependent protection against maximal electroshock seizures in mice with an ED₅₀ of 3.8 (2.9-5.1) mg/kg.

Animal Model:	Adult male mice (10-week-old; 25-30 g; vincristine-induced peripheral neuropathy model)^[2].
Dosage:	10, 30, 60 mg/kg
Administration:	Intraperitoneal injection; single
Result:	Significantly decreased the percentage of NK1 receptors in the spinal cord at dosage of 60 mg/kg. Showed a sustained increase in paw withdrawal threshold against mechanical stimuli.

Molecular Weight

253.34

Formula

C₁₇H₁₉NO

CAS No.

13669-70-0

SMILES

CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Verleye M, et al. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004 Jul 9;1013(2):249-55. [Content Brief]

[2]. Lee JY, et al. The Antiallodynic Effect of Nefopam on Vincristine-Induced Neuropathy in Mice. J Pain Res. 2020 Feb 7;13:323-329. [Content Brief]

[3]. Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11. [Content Brief]

Nefopam Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nefopam13669-70-0FenazoxineOthersneuropathic painpostoperative shiveringpostoperative hiccupsanticonvulsantSK-N-SHInhibitorinhibitorinhibit

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