Nemorosone

Name: Nemorosone
Brand: MedChemExpress
SKU: HY-121458
Rating: 4.5 (1 reviews)

Cat. No.: HY-121458 Purity: ≥99.0%: FAQs
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Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells.

For research use only. We do not sell to patients.

Nemorosone Chemical Structure

CAS No. : 351416-47-2

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Based on 1 publication(s) in Google Scholar

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Description

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells^[1]^[2].

IC₅₀ & Target

apoptosis^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	6.23 μg/mL Compound: Nemorosone	Cytotoxicity against cisplatin-resistant human A2780 cells after 24 hrs Cytotoxicity against cisplatin-resistant human A2780 cells after 24 hrs	[PMID: 18951805]
A2780	IC₅₀	6.75 μg/mL Compound: Nemorosone	Cytotoxicity against doxorubicin-resistant human A2780 cells after 24 hrs Cytotoxicity against doxorubicin-resistant human A2780 cells after 24 hrs	[PMID: 18951805]
A2780	IC₅₀	9.2 μg/mL Compound: Nemorosone	Cytotoxicity against human A2780 cells after 24 hrs Cytotoxicity against human A2780 cells after 24 hrs	[PMID: 18951805]
HCT-8	IC₅₀	4.07 μg/mL Compound: Nemorosone	Cytotoxicity against SN38-resistant human HCT8 cells after 24 hrs Cytotoxicity against SN38-resistant human HCT8 cells after 24 hrs	[PMID: 18951805]
HCT-8	IC₅₀	4.23 μg/mL Compound: Nemorosone	Cytotoxicity against human HCT8 cells after 24 hrs Cytotoxicity against human HCT8 cells after 24 hrs	[PMID: 18951805]
HCT-8	IC₅₀	4.44 μg/mL Compound: Nemorosone	Cytotoxicity against raltitrexed-resistant human HCT8 cells after 24 hrs Cytotoxicity against raltitrexed-resistant human HCT8 cells after 24 hrs	[PMID: 18951805]
HEK293	IC₅₀	4.2 μg/mL Compound: Nemorosone	Cytotoxicity against HEK293 cells after 24 hrs Cytotoxicity against HEK293 cells after 24 hrs	[PMID: 18951805]
HeLa	IC₅₀	2.9 μM Compound: 3, Natural NEM	Cytotoxicity against human HeLa cells after 72 hrs by resazurin assay Cytotoxicity against human HeLa cells after 72 hrs by resazurin assay	[PMID: 22944119]
HeLa	IC₅₀	3.3 μM Compound: nemorosone	Cytotoxicity against human HeLa cells after 24 to 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 to 48 hrs by MTT assay	[PMID: 19497755]
HT-29	IC₅₀	3.5 μg/mL Compound: Nemorosone	Cytotoxicity against SN38-resistant human HT-29 cells after 24 hrs Cytotoxicity against SN38-resistant human HT-29 cells after 24 hrs	[PMID: 18951805]
HT-29	IC₅₀	5.18 μg/mL Compound: Nemorosone	Cytotoxicity against 5-FU-resistant human HT-29 cells after 24 hrs Cytotoxicity against 5-FU-resistant human HT-29 cells after 24 hrs	[PMID: 18951805]
HT-29	IC₅₀	5.25 μg/mL Compound: Nemorosone	Cytotoxicity against human HT-29 cells after 24 hrs Cytotoxicity against human HT-29 cells after 24 hrs	[PMID: 18951805]
Jurkat	IC₅₀	4.6 μg/mL Compound: Nemorosone	Cytotoxicity against human Jurkat cells after 24 hrs Cytotoxicity against human Jurkat cells after 24 hrs	[PMID: 18951805]
K562	IC₅₀	4.2 μg/mL Compound: Nemorosone	Cytotoxicity against human K562 cells after 24 hrs Cytotoxicity against human K562 cells after 24 hrs	[PMID: 18951805]
LNCaP	IC₅₀	1.81 μg/mL Compound: Nemorosone	Cytotoxicity against etoposide-resistant human LNCAP cells after 24 hrs Cytotoxicity against etoposide-resistant human LNCAP cells after 24 hrs	[PMID: 18951805]
LNCaP	IC₅₀	2.12 μg/mL Compound: Nemorosone	Cytotoxicity against human LNCAP cells after 24 hrs Cytotoxicity against human LNCAP cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	3.3 μg/mL Compound: Nemorosone	Cytotoxicity against 5-FU-resistant human MCF7 cells after 24 hrs Cytotoxicity against 5-FU-resistant human MCF7 cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	4.28 μg/mL Compound: Nemorosone	Cytotoxicity against doxorubicin-resistant human MCF7 cells after 24 hrs Cytotoxicity against doxorubicin-resistant human MCF7 cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	4.37 μg/mL Compound: Nemorosone	Cytotoxicity against human MCF7 cells after 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	5.2 μM Compound: 3, Natural NEM	Cytotoxicity against human MCF7 cells after 72 hrs by resazurin assay Cytotoxicity against human MCF7 cells after 72 hrs by resazurin assay	[PMID: 22944119]
MIA PaCa-2	IC₅₀	2.4 μM Compound: 3, Natural NEM	Cytotoxicity against human MIAPaCa2 cells after 72 hrs by resazurin assay Cytotoxicity against human MIAPaCa2 cells after 72 hrs by resazurin assay	[PMID: 22944119]
NCI-H460	IC₅₀	4.21 μg/mL Compound: Nemorosone	Cytotoxicity against human H460 cells after 24 hrs Cytotoxicity against human H460 cells after 24 hrs	[PMID: 18951805]
NIH3T3	IC₅₀	> 50 μg/mL Compound: Nemorosone	Cytotoxicity against Swiss mouse 3T3 cells after 24 hrs Cytotoxicity against Swiss mouse 3T3 cells after 24 hrs	[PMID: 18951805]
PC-3	IC₅₀	2.01 μg/mL Compound: Nemorosone	Cytotoxicity against human PC3 cells after 24 hrs Cytotoxicity against human PC3 cells after 24 hrs	[PMID: 18951805]

In Vitro

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC₅₀s of 25.7-27.1 μM, 22.8-64.3 μM, respectively^[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells^[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HT-29 and LoVo cells
Concentration:	0-50 μM
Incubation Time:	24-72 h
Result:	Inhibited the proliferation of HT-29 and LoVo cells with IC₅₀s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.

Cell Cycle Analysis^[1]

Cell Line:	HT-29 and LoVo cells
Concentration:	25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time:	24, 48 hours
Result:	Increased the percentage of G0/G1 phase cells.

Apoptosis Analysis^[1]

Cell Line:	HT-29 and LoVo cells
Concentration:	25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time:	24, 48 hours
Result:	Induced apoptosis in both cell lines.

In Vivo

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm³ MIA-PaCa-2 xenograft tumor^[2]
Dosage:	50 mg/kg
Administration:	Daily i.p. injections for 28 days
Result:	Showed a significant growth-inhibitory effect in pancreatic cancer xenografts^[2].

Molecular Weight

502.68

Formula

C₃₃H₄₂O₄

CAS No.

351416-47-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)[C@@]23C([C@@](C(C(C/C=C(C)/C)=C2O)=O)(C[C@H](C/C=C(C)/C)C3(C)C)C/C=C(C)/C)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (280 KB) SDS (251 KB)

COA (261 KB)

Handling Instructions (2659 KB)

References

[1]. Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5):1827. Published 2020 Mar 6. [Content Brief]

[2]. Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8(9):e74555. Published 2013 Sep 5. [Content Brief]

Nemorosone Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemorosone351416-47-2ApoptosisCancerHT-29 cellsLoVo cellsMIA-PaCa-2 cellsantiproliferativeInhibitorinhibitorinhibit

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