NEU617

Cat. No.: HY-125084: FAQs
Data Sheet Handling Instructions

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NEU617 is an anti-parasite agent. NEU617 inhibits the proliferation for the HAT (human African trypanosomiasis) pathogen (EC₅₀: 42 nM for Trypanosoma brucei, 1.8 μM for T. cruzi). NEU617 is a derivative of Lapatinib (HY-50898).

For research use only. We do not sell to patients.

NEU617 Chemical Structure

CAS No. : 1432450-82-2

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
3T3	EC₅₀	1.8 μM Compound: 4; NEU-617	Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in rat 3T3 cells after 48 hrs by chlorophenol red-beta-D-galactopyranoside based assay Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in rat 3T3 cells after 48 hrs by chlorophenol red-beta-D-galactopyranoside based assay	[PMID: 28337329]
HepG2	IC₅₀	> 20 μM Compound: 23a, NEU617	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23597080]
RAW264.7	EC₅₀	> 8 μM Compound: 4; NEU-617	Antileishmanial activity against luciferase-expressing Leishmania major amastigotes infected in mouse RAW264.7 cells after 96 hrs by luminescence assay Antileishmanial activity against luciferase-expressing Leishmania major amastigotes infected in mouse RAW264.7 cells after 96 hrs by luminescence assay	[PMID: 28337329]
RAW264.7	EC₅₀	8 μM Compound: 1	Antiparasite activity against luciferase-expressing Leishmania major amastigotes isolated from infected in mouse RAW264.7 cells assessed as growth inhibition incubated for 96 hrs by luciferase reporter gene assay Antiparasite activity against luciferase-expressing Leishmania major amastigotes isolated from infected in mouse RAW264.7 cells assessed as growth inhibition incubated for 96 hrs by luciferase reporter gene assay	[PMID: 26087257]

Molecular Weight

541.02

Formula

C₃₁H₂₆ClFN₄O₂

CAS No.

1432450-82-2

SMILES

FC1=CC(COC2=CC=C(NC3=C4C=C(C5=CC=CC(N6CCOCC6)=C5)C=CC4=NC=N3)C=C2Cl)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Devine W, et al. Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery. J Med Chem. 2015 Jul 23;58(14):5522-37. [Content Brief]

NEU617 Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NEU6171432450-82-2NEU 617NEU-617ParasiteAnti-ParasitetrypanosomiasisInhibitorinhibitorinhibit

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