Neuraminidase-IN-10 

Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with  anti-influenza activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC₅₀ values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively^[1].

Neuraminidase-IN-10 displays promising anti-influenza virus activity with EC₅₀ value of 7.28 and 0.71μM for H5N1 and H5N8, respectively in CEFs. Neuraminidase-IN-10 displays anti-influenza virus activity with EC₅₀ values of 0.04 ± 0.04 and 28.70 ± 1.61 μM, respectively in MDCK Cells^[1].
Metabolic stability is an important indicator for the assessment of drug candidates. Neuraminidase-IN-10 exhibits a T_1/2 (min), CL_int(mic) (μL/min/kg), CL_{int (liver)} (mL/min/kg) and remaining (T=60 min)(%) values of 120.5 min, 11.5 μL/min/kg, 10.4 mL/min/kg and 73.8 mins, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

486.62

C₂₆H₃₄N₂O₅S

2685786-29-0

O=C(C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](NCC2=CC=C(C3=CC=CS3)C=C2OC)C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Han Ju, et al. Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity. J Med Chem. 2022 Aug 8. doi: 10.1021/acs.jmedchem.1c01970.  [Content Brief]