2. Anti-infection
  3. Influenza Virus
  4. Neuraminidase-IN-16

Neuraminidase-IN-16 (Compound 43b) is a potent neuraminidase inhibitor with IC50s of 0.031, 0.15, 0.25, 0.60, 0.63 and 10.08 μM against neuraminidase of H5N1, H5N8, H1N1, H3N2, H5N1-H274Y and H1N1-H274Y, respectively.

For research use only. We do not sell to patients.

Neuraminidase-IN-16 Chemical Structure

Neuraminidase-IN-16 Chemical Structure

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Neuraminidase-IN-16 Related Antibodies

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Description

Neuraminidase-IN-16 (Compound 43b) is a potent neuraminidase inhibitor with IC50s of 0.031, 0.15, 0.25, 0.60, 0.63 and 10.08 μM against neuraminidase of H5N1, H5N8, H1N1, H3N2, H5N1-H274Y and H1N1-H274Y, respectively[1].

In Vitro

Neuraminidase-IN-16 (Compound 43b; 48 h) shows anti-influenza virus activity with EC50s of 2.10±0.44 μM and 2.28±0.67 μM for H5N1 and H5N8, respectively in Chicken Embryo Fibroblast cells (CEFs)[1].
Neuraminidase-IN-16 (48 h) shows anti-influenza virus activity with EC50s of 0.20±0.01 μM and 11.3±2.5 μM for H1N1 and H3N2, respectively in MDCK cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuraminidase-IN-16 Related Antibodies
In Vivo

Neuraminidase-IN-16 (Compound 43b; 0.039-10 mM; 100 uL) shows anti-influenza virus activity in specific pathogen free (SPF) chicken embryonated egg[1].
Neuraminidase-IN-16 has no ability to pass through the blood-brain barrier[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SPF chicken embryonated egg infected with H5N1 and H5N8 virus strains[1]
Dosage: 0.039, 0.156, 0.625, 2.5 and 10 mM; 100 uL
Administration: A 1 mm diameter hole was drilled into the egg shell on the side where the embryo was located, the mixture was injected into the egg, and the holes were sealed by wax.
Result: Showed 100% protective effect at the highest tested concentration (10 mM).
Molecular Weight

458.57

Formula

C26H35FN2O4
SMILES

CCC(O[C@@H]1C=C(C[C@@H]([C@H]1NC(C)=O)NCC2=CC=C(C(F)=C2)C3=CCCC3)C(O)=O)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neuraminidase-IN-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuraminidase-IN-16Influenza VirusMDCKCEFsChicken Embryo Fibroblast cellschicken embryonated eggH5N1H5N8H1N1H3N2H5N1–H274YH1N1–H274YInhibitorinhibitorinhibit

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