Neuropeptide W-23 (human) (TFA) (Synonyms: NPW-23 TFA)

Cat. No.: HY-P1035A: FAQs
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Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).

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Neuropeptide W-23 (human) (TFA) Chemical Structure

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Other In-stock Forms of Neuropeptide W-23 (human) (TFA):

Neuropeptide W-23 (human)

Other Forms of Neuropeptide W-23 (human) (TFA):

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Description

Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8)^[1].

IC₅₀ & Target

NPBW1, NPBW2^[1]

In Vitro

Neuropeptide W-23 (human) (NPW-23) increases the I_Ca,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7^[1].
Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats^[2].
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Harlan Sprague-Dawley rats, 250–300 g^[2]
Dosage:	0.3, 1.0 and 3.0 nM
Administration:	Intracerebroventricular injection, 2 μL
Result:	Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.

Animal Model:	Male Wistar rats weighing 250–300 g^[3]
Dosage:	2, 4, 6 and 8 nM
Administration:	Intra-cerebroventricular injection, 10 μL
Result:	Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.

Molecular Weight

2698.03

Formula

C₁₁₉H₁₈₃N₃₅O₂₈S.C₂HF₃O₂

Sequence

Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-LeuMet-Gly-Leu

Sequence Shortening

WYKHVASPRYHTVGRAAGLLMGL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42. [Content Brief]

[2]. Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10. [Content Brief]

[3]. Naso T, et al. Central neuropeptide W has anorexigenic effect in rats. J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):228-34. [Content Brief]

Neuropeptide W-23 (human) (TFA) Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuropeptide W-23 (human) (TFA)NPW-23NPW23NPW 23OthersNPBW1NPBW2GPR7GPR8Neuropeptide Whypetensionanorexigenic effectInhibitorinhibitorinhibit

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