NF-κB-IN-16 

NF-κB-IN-16 (compound 9) is a complex (Pt(IV) complex) of NF-κB inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-κB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-κB-IN-16 potently inhibits the NF-κB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-κB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models^[1].

NF-κB-IN-16 (compound 9) (5 μM; 24 h) induces apoptosis in A549 cells, exhibited cell cycle arrest at the S phase^[1].
And NF-κB-IN-16 shows cytotoxicity against human cancer cells with IC₅₀s of 0.45 μM (HepG-2), 0.46 μM (HCT-116), 0.73 μM (MCF-7), and 0.29 μM (A549), respectively^[1].
NF-κB-IN-16 (5 μM; 24 h) could induce DNA damage in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-16 (compound 9) (5, 13.9 mg/kg; ip; 21 d) showed excellent anti-tumor efficacy in the A549 xenograft nude mouse model, with an inhibition rate of 36.2 at two doses. % and 63.7%^[1].
NF-κB-IN-16 also showed significant inhibitory effects on the A549/CDPP xenograft nude mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

837.01

C₂₆H₃₅Cl₃N₂O₁₀Pt

COC1=C(C(OC)=CC(C(/C=C/C2=CC=C(C(OCCOC(CCCC(O[Pt]([NH3])(Cl)(Cl)([NH3])Cl)=O)=O)=C2)OC)=O)=C1)OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang M, et al. Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance. J Med Chem. 2024 Apr 25;67(8):6218-6237.  [Content Brief]