2. NF-κB
  3. NF-κB
  4. NF-κB-IN-3

NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC50 of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent.

For research use only. We do not sell to patients.

NF-κB-IN-3 Chemical Structure

NF-κB-IN-3 Chemical Structure

CAS No. : 1873311-82-0

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NF-κB-IN-3 Related Antibodies

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC50 of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent[1].

IC50 & Target

NF-κB

0.70 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
ACHN GI50
0.526 μM
Compound: 6g
Cytotoxicity against human ACHN cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human ACHN cells after 72 hrs by sulforhodamine B assay
[PMID: 27096046]
HCT-15 GI50
0.797 μM
Compound: 6g
Cytotoxicity against human HCT15 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HCT15 cells after 72 hrs by sulforhodamine B assay
[PMID: 27096046]
MDA-MB-231 GI50
0.288 μM
Compound: 6g
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
[PMID: 27096046]
NCI-H23 GI50
0.292 μM
Compound: 6g
Cytotoxicity against human NCI-H23 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H23 cells after 72 hrs by sulforhodamine B assay
[PMID: 27096046]
NUGC-3 GI50
0.754 μM
Compound: 6g
Cytotoxicity against human NUGC3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human NUGC3 cells after 72 hrs by sulforhodamine B assay
[PMID: 27096046]
PC-3 GI50
0.729 μM
Compound: 6g
Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
[PMID: 27096046]
RAW264.7 IC50
0.7 μM
Compound: 6g
Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
[PMID: 27096046]
Molecular Weight

458.86

Formula

C24H18ClF3N2O2
CAS No.
SMILES

O=C(C1CCC2=CC=CC=C2N1C(C3=CC=CC(Cl)=C3)=O)NC4=CC=CC=C4C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NF-κB-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-31873311-82-0NF-κBNuclear factor-κBNuclear factor-kappaBanticancerNUGC-3ACNHNCIH23HCT15MDAMB-231PC-3Inhibitorinhibitorinhibit

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