2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. NF110

NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons.

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NF110 Chemical Structure

NF110 Chemical Structure

CAS No. : 111150-22-2

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Based on 1 publication(s) in Google Scholar

NF110 Related Antibodies

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Description

NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1].

IC50 & Target

Ki: 36 nM (P2X3 Receptor)
In Vitro

NF110 shows an activity in the human tumour cell line panel, with IC30 of 362.3 μM[2].
NF110 inhibits HMGA2-DNA interactions with an IC50 of 0.87 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NF110 Related Antibodies
In Vivo

NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1096.91

Formula

C41H28N6Na4O17S4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC(C(NC2=CC=C(S(=O)(O[Na])=O)C=C2)=O)=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C=C3)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O[Na])=O)C=C5)=O)=CC(C(NC6=CC=C(S(=O)(O[Na])=O)C=C6)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 40 mg/mL (36.47 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9117 mL 4.5583 mL 9.1165 mL
5 mM 0.1823 mL 0.9117 mL 1.8233 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 93.6%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9117 mL 4.5583 mL 9.1165 mL 22.7913 mL
5 mM 0.1823 mL 0.9117 mL 1.8233 mL 4.5583 mL
10 mM 0.0912 mL 0.4558 mL 0.9117 mL 2.2791 mL
15 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5194 mL
20 mM 0.0456 mL 0.2279 mL 0.4558 mL 1.1396 mL
25 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.9117 mL
30 mM 0.0304 mL 0.1519 mL 0.3039 mL 0.7597 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NF110 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF110111150-22-2NF 110NF-110P2X ReceptorP2XRsP2Yalphabeta-methylene-ATP-inducedcurrentsInhibitorinhibitorinhibit

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