2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. NH2-C5-PEG4-N3-L-Lysine-PEG3-N3

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 Chemical Structure

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 Chemical Structure

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NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 Related Antibodies

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Description

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 Related Antibodies
Molecular Weight

619.71

Formula

C25H49N9O9
SMILES

O=C([C@H](CCCCN)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)NCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
NH2-C5-PEG4-N3-L-Lysine-PEG3-N3
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HY-130946
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