Nitric oxide production-IN-2

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TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is inhibitors of TLR4, JNK, and NF-κB. TLR4/JNK/NF-κB-IN-1 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC₅₀ value of 23.2 µM. TLR4/JNK/NF-κB-IN-1 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB, blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4/JNK/NF-κB-IN-1 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders.

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Nitric oxide production-IN-2 Chemical Structure

CAS No. : 1019984-44-1

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JNK1 JNK2 JNK3 JNK

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description	TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is inhibitors of TLR4, JNK, and NF-κB. TLR4/JNK/NF-κB-IN-1 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC₅₀ value of 23.2 µM. TLR4/JNK/NF-κB-IN-1 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB, blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4/JNK/NF-κB-IN-1 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders^[1].
Molecular Weight	344.40
Formula	C₂₃H₂₀O₃
CAS No.	1019984-44-1
SMILES	O=C1C2=CC=C(C=C2C(C1C3=CC=C(C=C3)OC)C4=CC=CC=C4)OC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Tang ML, et al. Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents. Eur J Med Chem. 2016 May 4;113:63-74. [Content Brief]