2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-45

NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation, inhibiting the activity of IL-1β (IC50=41.79 nM). NLRP3-IN-45 exerts its effects without affecting the initial stage of NLRP3 inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of NLRP3 inflammasome in the LPS-induced acute lung injury (ALI) mouse model.

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NLRP3-IN-45 Chemical Structure

NLRP3-IN-45 Chemical Structure

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NLRP3-IN-45 Related Antibodies

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Description

NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation, inhibiting the activity of IL-1β (IC50=41.79 nM). NLRP3-IN-45 exerts its effects without affecting the initial stage of NLRP3 inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of NLRP3 inflammasome in the LPS-induced acute lung injury (ALI) mouse model[1].

IC50 & Target

NLRP3 inflammasome

 

In Vitro

NLRP3-IN-45 (0.2-5 μM, 1 h) inhibits the activation of NLRP3 inflammasome in BMDMs cells, and does not affect the activation of AIM2 and NLRC4 inflammasomes[1].
NLRP3-IN-45 (0.2-5 μM, 1 h) does not affect the initiation phase of NLRP3 inflammasome activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NLRP3-IN-45 Related Antibodies

Western Blot Analysis[1]

Cell Line: a NLRP3 inflammasome model in BMDMs cells; a AIM2 and NLRC4 inflammasome model in BMDMs cells
Concentration: 0.2, 1, 5 μM
Incubation Time: 1 h
Result: Inhibited the secretion of IL-1β and Caspase-1 mediated by NLRP3 inflammasome in a concentration-dependent manner[1].
Had no significant effect on the expression of TNF-α, Pro-IL-1β, Pro-caspase-1, NLRP3 and ASC proteins[1].
Had no effect on the secretion of IL-1β and Caspase-1 mediated by AIM2 and NLRC4 inflammasome[1].
In Vivo

NLRP3-IN-45 (0.1-10 mg/kg, once a day, 3 days, i.p.) inhibits the activation of NLRP3 inflammasome in an acute lung injury mouse model and has a protective effect against acute lung injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced ALI mice[1]
Dosage: 0.1, 1, 10 mg/kg; once a day; 3 days
Administration: Intraperitoneal injection (i.p.)
Result: Made the mice appear more active and the mice lost weight[1].
Reduced serum levels of IL-6, TNF-α, IL-1β, and BALF in a dose-dependent manner[1].
Weakened lung tissue lesions and significantly inhibited the secretion of IL-1β and Caspase-1 mediated by NLRP3 inflammasome activation[1].
Molecular Weight

483.53

Formula

C27H30FNO6
SMILES

O[C@@]12[C@@H](O)[C@]3([H])C(C)(C)CC=C[C@@]3(CO2)[C@@]4([H])[C@]1(C5=O)[C@H](OC(NC6=CC=C(F)C=C6)=O)[C@H](C5=C)CC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLRP3-IN-45 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-45NOD-like Receptor (NLR)A NLRP3 inflammasome model in mouseAcute lung injuryInflammasome activationInhibitorinhibitorinhibit

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