2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-74

NLRP3-IN-74 (Compound 11) is an orally active NLRP3 inhibitor with an IC50 value of 2.7 μM. NLRP3-IN-74 can inhibit the release of IL-1β, reducing the release level by approximately 90%, and does not inhibit the release of TNFα. NLRP3-IN-74 can be used in the research of related diseases such as atherosclerosis and Parkinson's disease.

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NLRP3-IN-74 Chemical Structure

NLRP3-IN-74 Chemical Structure

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NLRP3-IN-74 Related Antibodies

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Description

NLRP3-IN-74 (Compound 11) is an orally active NLRP3 inhibitor with an IC50 value of 2.7 μM. NLRP3-IN-74 can inhibit the release of IL-1β, reducing the release level by approximately 90%, and does not inhibit the release of TNFα. NLRP3-IN-74 can be used in the research of related diseases such as atherosclerosis and Parkinson's disease[1].

IC50 & Target

NLRP3

2.7 μM (IC50)

Molecular Weight

382.41

Formula

C20H22N4O4
SMILES

O=C(N1C2CCN(C([C@@H](C)NC(C3=CC=CO3)=O)=O)CC2)NC4=C1C=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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NLRP3-IN-74 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-74NOD-like Receptor (NLR)Inhibitorinhibitorinhibit

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