Norlichexanthone (Synonyms: Fusarindin)

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Norlichexanthone is a compound isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae.

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Norlichexanthone Chemical Structure

CAS No. : 20716-98-7

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Description

Norlichexanthone is a compound isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	> 10 μM Compound: 4	Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31359750]
A2780	IC₅₀	68.2 μM Compound: 7	Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay	[PMID: 21741249]
A2780	IC₅₀	74 μM Compound: 7	Antiproliferative activity against human cisplatin resistant A2780 cells after 24 hrs by MTT assay Antiproliferative activity against human cisplatin resistant A2780 cells after 24 hrs by MTT assay	[PMID: 21741249]
HT-29	IC₅₀	> 20 μM Compound: 5	Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay	[PMID: 28409637]
K562	IC₅₀	253.5 μM Compound: 7	Antiproliferative activity against human K562 cells after 24 hrs by MTT assay Antiproliferative activity against human K562 cells after 24 hrs by MTT assay	[PMID: 21741249]
L5178Y	IC₅₀	> 10 μM Compound: 4	Cytotoxicity against mouse L5178Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against mouse L5178Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31359750]
L5178Y	IC₅₀	1.16 μM Compound: 7	Antiproliferative activity against mouse L5178Y cells after 24 hrs by MTT assay Antiproliferative activity against mouse L5178Y cells after 24 hrs by MTT assay	[PMID: 21741249]
MCF7	IC₅₀	> 20 μM Compound: 5	Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay	[PMID: 28409637]
RAW264.7	IC₅₀	35.2 μM Compound: 12	Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay	[PMID: 35007071]

Molecular Weight

258.23

Formula

C₁₄H₁₀O₅

CAS No.

20716-98-7

SMILES

O=C1C2=C(C=C(O)C=C2C)OC3=CC(O)=CC(O)=C13

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu F, et al. The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce [published correction appears in Planta Med. 2010 Jan;76(2):e9]. Planta Med. 2010;76(2):185-189. [Content Brief]

Norlichexanthone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norlichexanthone20716-98-7FusarindinOthersInhibitorinhibitorinhibit

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