2. Metabolic Enzyme/Protease
  3. NADPH Oxidase
  4. NoxA1ds

NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NoxA1ds Chemical Structure

NoxA1ds Chemical Structure

CAS No. : 1435893-78-9

Size Price Stock Quantity
1 mg USD 120 In-stock
5 mg USD 300 In-stock
10 mg USD 480 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of NoxA1ds:

NoxA1ds Related Antibodies

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NOX1 NOX2 NOX4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia[1].

IC50 & Target

NOX1

 

Molecular Weight

1125.32

Formula

C50H88N14O15
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

EPVDALGKAKV-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (88.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8886 mL 4.4432 mL 8.8864 mL
5 mM 0.1777 mL 0.8886 mL 1.7773 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (88.86 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8886 mL 4.4432 mL 8.8864 mL 22.2159 mL
5 mM 0.1777 mL 0.8886 mL 1.7773 mL 4.4432 mL
10 mM 0.0889 mL 0.4443 mL 0.8886 mL 2.2216 mL
15 mM 0.0592 mL 0.2962 mL 0.5924 mL 1.4811 mL
20 mM 0.0444 mL 0.2222 mL 0.4443 mL 1.1108 mL
25 mM 0.0355 mL 0.1777 mL 0.3555 mL 0.8886 mL
30 mM 0.0296 mL 0.1481 mL 0.2962 mL 0.7405 mL
40 mM 0.0222 mL 0.1111 mL 0.2222 mL 0.5554 mL
50 mM 0.0178 mL 0.0889 mL 0.1777 mL 0.4443 mL
60 mM 0.0148 mL 0.0741 mL 0.1481 mL 0.3703 mL
80 mM 0.0111 mL 0.0555 mL 0.1111 mL 0.2777 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NoxA1ds Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NoxA1ds1435893-78-9NADPH OxidaseNOXefficaciousselectiveNox1-NOXA1hypertensionatherosclerosisneoplasiaInhibitorinhibitorinhibit

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