2. GPCR/G Protein
  3. Orphan Receptor
  4. NR2E3 agonist 1

NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC50 value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research.

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NR2E3 agonist 1 Chemical Structure

NR2E3 agonist 1 Chemical Structure

CAS No. : 911211-69-3

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NR2E3 agonist 1 Related Antibodies

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Description

NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC50 value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
35 nM
Compound: 11a
Agonist activity at NR2E3 by luciferase NCOR release assay in CHO cells
Agonist activity at NR2E3 by luciferase NCOR release assay in CHO cells
[PMID: 16879962]
Molecular Weight

430.89

Formula

C24H19ClN4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CC1)NC2=CC=C(NC(C3=CC=C(NC(C4=CC=CC=C4Cl)=O)C=C3)=N5)C5=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.48%

SDS (251 KB)

COA (245 KB) HNMR (302 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References
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NR2E3 agonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NR2E3 agonist 1911211-69-3Orphan Receptorretinitis pigmentosaNuclear receptorRNRAge-related macular degenerationInhibitorinhibitorinhibit

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