Nrf2 activator 19 

Nrf2 activator 19 is a BBB-penetrable NRF2/HO-1 activator. Nrf2 activator 19 exerts potent antioxidant and neuroprotective effects. Nrf2 activator 19 can also effectively reduce brain damage, reduce Reactive Oxygen Species (ROS) accumulation. Nrf2 activator 19 inhibits neuronal apoptosis. Nrf2 activator 19 promotes the recovery of neurological function and motor ability. Nrf2 activator 19 shows significant potential in ischemic stroke research^[1].

Nrf2 activator 19 (Compound 6p) (40 μM, 24 h) shows no cytotoxicity in PC12 cells and RAW cells, the viability of PC12 cells under t-BHP injury could reach more than 90%, demonstrating a strong protective effect^[1].
Nrf2 activator 19 (2.5 μM-20 μM, 24 h) shows a good protective effect against t-BHP induced oxidative damage in PC12 cells^[1].
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) can effectively reduce ROS levels in PC12 cells, and shows a decrease in malondialdehyde (MDA) levels and an increase in superoxide dismutase (SOD) activity^[1].
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) increases the expression of NRF2 and HO-1 proteins in a concentration-dependent manner in PC12 cells, indicating that it protects against oxidative damage by activating the NRF2 pathway.
Nrf2 activator 19 (10 μM, 3 h) reduces KEAP1 expression in PC12 cells, indicating a direct interaction with KEAP1^[1].
Nrf2 activator 19 (1 μM, 1 h) shows moderate metabolic stability in rat liver microsomes^[1].
Nrf2 activator 19 (10 μM, 24 h) shows a permeability of 7.64% in the Transwell-based blood-brain barrier (BBB) model (bEnd.3 cells), indicating its ability to cross the BBB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nrf2 activator 19 (5-20 mg/kg, i.v. , 7 consecutive days) improves neurological recovery in a rat cerebral ischemia-reperfusion injury (MCAO) model and protects against ischemia-reperfusion injury by activating the NRF2 pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

400.42

C₂₅H₂₀O₅

OC1=CC=C(C(/C=C/C2=C3C(OC(C4=CC=C(C)C=C4)=C3)=C(OC)C=C2)=O)C=C1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Su W, et al. Design, synthesis and biological evaluation of 2-arylbenzo[b]furan-4-vinylcarbonyl derivatives based on Salvianolic acid C as antioxidant neuroprotective agents for the treatment of ischemic stroke. Eur J Med Chem. 2025 Mar 13;290:117506.  [Content Brief]