Nrf2 activator-7

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Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.

For research use only. We do not sell to patients.

Nrf2 activator-7 Chemical Structure

CAS No. : 2456295-39-7

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Description

Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.

In Vitro

The binding activity of Nrf2 activator-7 to Keap1 has an IC₅₀ value of 85 nM by fluorescence polarization (FP) assay, an IC₅₀ value of 13.1 nM by time-resolved fluorescence energy transfer (TR-FRET) assay, and a K_i value of 4.9 nM^[1].
Nrf2 activator-7 (1, 10, 100 μM; 24 h) increases in the transcription of Nrf2 target genes (GSTM3, HMOX1 and NQO1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	NCM460D cells
Concentration:	1, 10, 100 μM
Incubation Time:	24 h
Result:	Significantly increased transcription of Nrf2 target genes (GSTM3, HMOX1 and NQO1) at 100 μM.

Molecular Weight

720.77

Formula

C₃₅H₃₂N₂O₁₁S₂

CAS No.

2456295-39-7

SMILES

COC1=CC=C(C=C1)C2=C(C3=C(C(N(S(=O)(C4=CC=C(C=C4)OC)=O)CC(O)=O)=C2)C=CC=C3)N(S(=O)(C5=CC=C(C=C5)OC)=O)CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator-72456295-39-7Keap1-Nrf2NCM460D cellsNrf2Inhibitorinhibitorinhibit

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