2. PROTAC NF-κB
  3. PROTACs Keap1-Nrf2
  4. Nrf2 degrader 1

Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively.

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Nrf2 degrader 1 Chemical Structure

Nrf2 degrader 1 Chemical Structure

CAS No. : 3025286-00-1

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Based on 1 publication(s) in Google Scholar

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Description

Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively[1].

Molecular Weight

826.92

Formula

C45H42N6O8S
CAS No.
SMILES

O=C1NC(C(N2C(C(C(NCCOCCOC3=CC(CC(NC4=NC(C5=CC=C(N(C(C6=C(C)C=CC=C6)=O)CC7)C7=C5)=C(C)S4)=O)=CC=C3)=CC=C8)=C8C2=O)=O)CC1)=O
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Room temperature in continental US; may vary elsewhere.
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Nrf2 degrader 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 degrader 13025286-00-1PROTACsKeap1-Nrf2Nrf2 degraderPROTACanticancer effectsInhibitorinhibitorinhibit

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