2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. NS-220

NS-220 is an orally active PPARα agonist with high subtype selectivity, with EC50 values of 1.9×10-8 M, 9.6×10-6 M and >10-4 M for PPARα, PPAR γ and PPARδ, respectively. NS-220 is used in the research for hyperlipidemia or metabolic disorders in type-2 diabetes.

For research use only. We do not sell to patients.

NS-220 Chemical Structure

NS-220 Chemical Structure

CAS No. : 377731-45-8

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NS-220 Related Antibodies

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Description

NS-220 is an orally active PPARα agonist with high subtype selectivity, with EC50 values of 1.9×10-8 M, 9.6×10-6 M and >10-4 M for PPARα, PPAR γ and PPARδ, respectively. NS-220 is used in the research for hyperlipidemia or metabolic disorders in type-2 diabetes[1].

IC50 & Target[1]

PPARα

19 nM (EC50)

PPARγ

9.6 μM (EC50)

PPARδ

>1 mM (EC50)

Molecular Weight

373.44

Formula

C21H27NO5
CAS No.
SMILES

O=C([C@]1(C)OC[C@H](CCCCC2=C(C)OC(C3=CC=C(C)C=C3)=N2)CO1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NS-220 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS-220377731-45-8NS220NS 220PPARPeroxisome proliferator-activated receptorsPPARαhyperlipidemiametabolic disorderInhibitorinhibitorinhibit

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