2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Autophagy
  3. JAK Autophagy
  4. NSC 33994

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM.

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NSC 33994 Chemical Structure

NSC 33994 Chemical Structure

CAS No. : 82058-16-0

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NSC 33994 Related Antibodies

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Description

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].

IC50 & Target[1]

JAK2

60 nM (IC50, JAK2 Val617Phe kinase activity )

In Vitro

NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner[1].
NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 33994 Related Antibodies
Molecular Weight

438.65

Formula

C28H42N2O2
CAS No.
SMILES

CC/C(C1=CC=C(O)C(CN(CC)CC)=C1)=C(C2=CC=C(O)C(CN(CC)CC)=C2)/CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSC 33994 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 3399482058-16-0NSC33994NSC-33994JAKAutophagyJanus kinaseInhibitorinhibitorinhibit

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