NSC126405

Cat. No.: HY-164385: FAQs
Data Sheet Handling Instructions

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NSC126405 is a mTOR-DEPTOR inhibitor that binds to DEPTOR, prevents mTOR-DEPTOR binding and induces multiple myeloma (MM) cytotoxicity. NSC126405 can be utilized in cancer research.

For research use only. We do not sell to patients.

NSC126405 Chemical Structure

CAS No. : 17581-52-1

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Biological Activity
Purity & Documentation
References
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Description

NSC126405 is a mTOR-DEPTOR inhibitor that binds to DEPTOR, prevents mTOR-DEPTOR binding and induces multiple myeloma (MM) cytotoxicity. NSC126405 can be utilized in cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MM1.S	IC₅₀	3 μM Compound: B; NSC126405	Cytotoxicity against human MM1S cells after 48 hrs by MTT assay Cytotoxicity against human MM1S cells after 48 hrs by MTT assay	[PMID: 28916338]
PBL	IC₅₀	20 μM Compound: B; NSC126405	Cytotoxicity against PBL (unknown origin) after 48 hrs by MTT assay Cytotoxicity against PBL (unknown origin) after 48 hrs by MTT assay	[PMID: 28916338]
RPMI-8226	IC₅₀	1.3 μM Compound: B; NSC126405	Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay	[PMID: 28916338]

Molecular Weight

231.89

Formula

C₅H₂Cl₄N₂

CAS No.

17581-52-1

SMILES

ClC(C(Cl)=C/1Cl)=C(Cl)C1=N\N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shi Y, et al. Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells. Cancer Res. 2016 Oct 1;76(19):5822-5831. [Content Brief]

NSC126405 Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC12640517581-52-1NSC 126405NSC-126405mTORMammalian target of RapamycinmTOR-DEPTOR inhibitormultiple myelomacancerInhibitorinhibitorinhibit

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