2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. NT376

NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases.

For research use only. We do not sell to patients.

NT376 Chemical Structure

NT376 Chemical Structure

CAS No. : 2820208-97-5

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NT376 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases[1].

IC50 & Target[1]

HDAC4

1.26 nM (IC50, HT-29 cells)

HDAC5

2.85 nM (IC50, HT-29 cells)

HDAC1

1483 nM (IC50, HT-29 cells)

HDAC11

4851 nM (IC50, HT-29 cells)

Class I/IIb

>4000 nM (IC50, HT-29 cells)

HDAC6

5035 nM (IC50, HT-29 cells)

In Vitro

NT376 (1.26-5035 nM, 3 h) exhibits high selectivity and high potency to class-IIa Histone deacetylases (HDAC)s (IC50=32 nM) over other HDAC classes (IC50= >4.0 µM), performing slightly better than NT160 (HY-149285) in the functional cell-based assay in HT-29 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NT376 Related Antibodies
Molecular Weight

436.40

Formula

C21H20F4N4O2
CAS No.
SMILES

O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NT376 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NT3762820208-97-5NT 376NT-376HDACHistone deacetylasesselectivityHT-29 cellscancersCNSAlzheimer’s diseaseHuntington’s diseaseInhibitorinhibitorinhibit

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