NU227326

Cat. No.: HY-173066: FAQs
Data Sheet Handling Instructions Technical Support

NU227326 is the PROTAC degrader for Indoleamine 2,3-dioxygenase 1 (IDO1) with DC₅₀ of 4.5 nM. NU227326 degrades IDO1 in cell U87 and GBM43 with DC₅₀ of 7.1 nM and 11.8 nM. NU227326 exhibits good pharmacokinetic properties with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours.(Pink: ligand for target protein IDO1 ligand-1 (HY-173067); Black: linker (HY-173068); Blue: ligand for E3 ligase Cereblon (HY-W087383))

For research use only. We do not sell to patients.

NU227326 Chemical Structure

CAS No. : 3048196-52-4

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PROTACs Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

View All Isoforms

IDO1 IDO2 IDO

Biological Activity
Purity & Documentation
References
Customer Review

Description

NU227326 is the PROTAC degrader for Indoleamine 2,3-dioxygenase 1 (IDO1) with DC₅₀ of 4.5 nM. NU227326 degrades IDO1 in cell U87 and GBM43 with DC₅₀ of 7.1 nM and 11.8 nM. NU227326 exhibits good pharmacokinetic properties with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours^[1].(Pink: ligand for target protein IDO1 ligand-1 (HY-173067); Black: linker (HY-173068); Blue: ligand for E3 ligase Cereblon (HY-W087383))

IC₅₀ & Target

IDO1

4.5 nM (DC₅₀)

Molecular Weight

941.10

Formula

C₅₃H₆₁FN₈O₇

CAS No.

3048196-52-4

SMILES

O=C(NC1=CC=CC(OC2CCN(C(CN3CCC(N4CCN(C5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)CC4)CC3)=O)CC2)=C1)[C@H](C)[C@@]8([H])CC[C@](C9=C%10C(C=CC(F)=C%10)=NC=C9)([H])CC8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Monsen PJ, et al., Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). J Med Chem. 2025 Feb 27;68(4):4961-4987. [Content Brief]

NU227326 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NU2273263048196-52-4NU 227326NU-227326PROTACsIndoleamine 2,3-Dioxygenase (IDO)U87GBM43Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *