2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. Nurr1 agonist 9

Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable.

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Nurr1 agonist 9 Chemical Structure

Nurr1 agonist 9 Chemical Structure

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Nurr1 agonist 9 Related Antibodies

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Description

Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable[1].

IC50 & Target

Nurr1/NR4A2

0.09 μM (EC50)

Nurr1/NR4A2

0.17 μM (Ki)

Molecular Weight

394.85

Formula

C21H19ClN4O2
SMILES

CC1=C(NC(C2=CC=C(C3=CC=C(N(C)C)C=C3)O2)=O)N(C=CC=C4Cl)C4=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nurr1 agonist 9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nurr1 agonist 9Nuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like ReceptorT98G astrocytesHEK293TParkinson’s DiseaseInhibitorinhibitorinhibit

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