O-Demethylforbexanthone

Cat. No.: HY-N3158: FAQs
Data Sheet Handling Instructions Technical Support

O-Demethylforbexanthone (7,9,12-Trihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one) is a Triterpenoids product that can be isolated from the herbs of Jatropha curcas..

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O-Demethylforbexanthone Chemical Structure

CAS No. : 92609-77-3

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Biological Activity
Purity & Documentation
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Description

O-Demethylforbexanthone (7,9,12-Trihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one) is a Triterpenoids product that can be isolated from the herbs of Jatropha curcas.^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4.7 μM Compound: 3	Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 24754786]
HCT-15	IC₅₀	5.1 μM Compound: 3	Cytotoxicity against human HCT15 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT15 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 24754786]
HeLa	IC₅₀	4.9 μM Compound: 3	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 24754786]
HepG2	IC₅₀	10.1 μM Compound: 3	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 24754786]
MCF7	IC₅₀	11.7 μM Compound: 3	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 24754786]
MCF7	IC₅₀	34.4 μM Compound: 3	Cytotoxicity against human MCF7 cells overexpressing HER2 assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells overexpressing HER2 assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 24754786]
MDA-MB-435	IC₅₀	3.9 μM Compound: 3	Cytotoxicity against human MDA-MB-435 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 24754786]

Molecular Weight

326.30

Formula

C₁₈H₁₄O₆

CAS No.

92609-77-3

SMILES

O=C1C2=CC3=C(C(O)=C2OC4=C1C(O)=CC(O)=C4)OC(C)(C)C=C3

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)