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  6. O-Demethylmurrayanine

O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 4.42-7.59 μg/mL.

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O-Demethylmurrayanine Chemical Structure

O-Demethylmurrayanine Chemical Structure

CAS No. : 123497-84-7

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O-Demethylmurrayanine Related Antibodies

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Description

O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 4.42-7.59 μg/mL[1].

Cellular Effect
Cell Line Type Value Description References
KB IC50
5.49 μM
Compound: 11
Cytotoxicity against human KB cells by resazurin microplate assay
Cytotoxicity against human KB cells by resazurin microplate assay
[PMID: 21302964]
NCI-H187 IC50
19.22 μM
Compound: 11
Cytotoxicity against human NCI-H187 by resazurin microplate assay
Cytotoxicity against human NCI-H187 by resazurin microplate assay
[PMID: 21302964]
Neutrophil IC50
3.5 μM
Compound: 18
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry
[PMID: 24798144]
Neutrophil IC50
6.9 μM
Compound: 18
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins
[PMID: 24798144]
Vero IC50
103.5 μM
Compound: 11
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
[PMID: 21302964]
Molecular Weight

211.22

Formula

C13H9NO2
CAS No.
SMILES

O=CC1=CC2=C(C(O)=C1)NC3=C2C=CC=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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O-Demethylmurrayanine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Demethylmurrayanine123497-84-7Othersphenolanticancer effectsInhibitorinhibitorinhibit

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