2. Epigenetics
  3. DNA Methyltransferase
  4. O6BTG-C8-αGlu

O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, O6BTG-C8-αGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 μM), it does not exhibit cytotoxicity. O6BTG-C8-αGlu is suitable for research on MGMT-related cancer diseases.

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O6BTG-C8-αGlu Chemical Structure

O6BTG-C8-αGlu Chemical Structure

CAS No. : 793035-88-8

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O6BTG-C8-αGlu Related Antibodies

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Description

O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, O6BTG-C8-αGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 μM), it does not exhibit cytotoxicity. O6BTG-C8-αGlu is suitable for research on MGMT-related cancer diseases[1].

Molecular Weight

616.53

Formula

C24H34BrN5O7S
CAS No.
SMILES

BrC1=CSC(COC2=C3C(N(C=N3)CCCCCCCCO[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=NC(N)=N2)=C1
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Purity & Documentation
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O6BTG-C8-αGlu Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O6BTG-C8-αGlu793035-88-8DNA MethyltransferaseDNMTsDNA MTasesInhibitorinhibitorinhibit

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