Octyl-α-ketoglutarate (Synonyms: 1-Octyl 2-oxopentanedioate)

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Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional TCA cycle, stimulating PHD activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.

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Octyl-α-ketoglutarate Chemical Structure

CAS No. : 876150-14-0

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Description	Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional TCA cycle, stimulating PHD activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD^[1].
Molecular Weight	258.31
Formula	C₁₃H₂₂O₅
CAS No.	876150-14-0
SMILES	O=C(OCCCCCCCC)C(CCC(O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (262 KB) Handling Instructions (2659 KB)
References	[1]. MacKenzie ED, et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol. 2007 May;27(9):3282-9. [Content Brief]

Octyl-α-ketoglutarate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octyl-α-ketoglutarate876150-14-01-Octyl 2-oxopentanedioateHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHα-ketoglutarateHEK293 cellsTCA cyclePHDInhibitorinhibitorinhibit

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Octyl-α-ketoglutarate (Synonyms: 1-Octyl 2-oxopentanedioate)

Octyl-α-ketoglutarate Related Antibodies

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•Related Small Molecules:

•Related Proteins:

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Biological Activity

Purity & Documentation

References

Customer Review