Odatroltide  (Synonyms: DHDMIQK(KAP))

Odatroltide, as a nanoscale P-selectin inhibitor, is a nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus^[1].

P-selectin^[1]

Odatroltide (1 nM) effectively down-regulates P-selectin expression. DHDMIQK(KAP) effectively inhibits platelet aggregation via down-regulating the expression of P-selectin. Odatroltide effectively inhibits platelet aggregations induced by TH, AA, ADP and PAF, which are correlated with the downregulation of P-selectin expression and with the scavenging of the free radicals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Odatroltide (0.01 nmol/kg) lyses the thrombus and inhibits thrombosis with a minimal^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

661.79

C₃₂H₅₁N₇O₈

1639303-73-3

CC1(C2=CC(O)=C(O)C=C2C[C@H](N1)C(N[C@H](C(O)=O)CCCCNC([C@H](CCCCN)NC([C@H](C)NC([C@@H]3CCCN3)=O)=O)=O)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Feng Q, et al. DHDMIQK(KAP): a novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus. J Mater Chem B. 2016;4(36):5991-6003.  [Content Brief]