2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) Bacterial
  4. ODN 1668 sodium

ODN 1668 sodium, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 sodium has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 sodium induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’.

For research use only. We do not sell to patients.

DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-T-G-C-T), sodium salt

ODN 1668 sodium Chemical Structure

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Based on 1 publication(s) in Google Scholar

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ODN 1668 sodium Related Antibodies

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Description

ODN 1668 sodium, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 sodium has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 sodium induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’[1][2][3][4].

IC50 & Target[4]

TLR9

 

In Vitro

Non-salt dose:
ODN 1668 (6-60 µg/mL; 12-72 h) increases the synthesis of S100A8/A9, IL-6 and β-galactosidase in mouse bone marrow derived macrophages[1].
ODN 1668 (24 h) promotes the activation and proliferation of B cells and increases the expression of CD86 and CD25[2].
ODN 1668 (0.3-3.0 μM; 4 days) promotes cell growth in anti-CD3-treated CD8+ T cells in a dose-dependent manner[2].
ODN 1668 (0.25-32 μg/mL; 12 h) promotes the proliferation of head kidney lymphocytes and enhances the expression of immune genes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ODN 1668 sodium Related Antibodies

Real Time qPCR[3]

Cell Line: Head kidney lymphocytes
Concentration: 2 μg/mL
Incubation Time: 12 h
Result: Increased the mRNA levels of TLR9, IL-1β, IL-6, IL-8, TNF-α, IFN-γ, MHC-Iα and MHC-IIα.
In Vivo

Non-salt dose:
ODN 1668 (10 nmol ≈ 63.6 μg; injection into the hind footpads; single dose) significantly enhances antibody response in OVA treated mice and increases titers of IgG2a and IgG2b[2].
ODN 1668 (15 μg; intramuscular injection; single dose) improves the antibacterial immunity of Epinephelus laminatus infection, and has the most significant antibacterial activity in liver, spleen and kidney[3].
ODN 1668 (1-5 mg/kg; intraperitoneal/subcutaneous injection; single dose) can cause fever, anorexia and brain inflammation in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (175-200 g)[4]
Dosage: 1 and 5 mg/kg
Administration: Intraperitoneal and subcutaneous injection, single dose
Result: Caused moderate fever and anorexia.
Induced a significant increase of IL-6.
Increased expression of inflammatory genes in the hypothalamus (SOCS3, PGE2, COX-2 and mPGES).
Activated inflammatory transcription factors in the rat brain (STAT3 and NF-IL6).
Appearance

Solid

Color

White to off-white

SMILES

[DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-T-G-C-T), sodium salt]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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ODN 1668 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 1668ODN1668ODN-1668Toll-like Receptor (TLR)Bacterialimmunostimulatory sequencevaccine adjuvantB cellsT cellsmacrophageshead kidney lymphocytesInhibitorinhibitorinhibit

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