2. Immunology/Inflammation Apoptosis
  3. Toll-like Receptor (TLR) Apoptosis
  4. ODN 1826

ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (ODN 1826 sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-C-G-T-T)

ODN 1826 Chemical Structure

CAS No. : 202668-42-6

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ODN 1826 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’[1][2][3][4].

IC50 & Target

TLR9

 

In Vitro

ODN 1826 (1 μg/mL, 24 h) can stimulate the production of NO and iNOS in RAW 264.7 cells [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ODN 1826 Related Antibodies

Western Blot Analysis[2]

Cell Line: RAW 264.7
Concentration: 1 μg/mL
Incubation Time: 24 h
Result: Increased the production of NO and iNOS.
In Vivo

ODN 1826 (18 nM, subcutaneous injection, 3 times a week for 7 weeks) increases aortic atherosclerotic plaque size in a mouse model of chronic vascular injury [1].
ODN 1826 (0.05 mg, intraperitoneally injected , 1, 3, 5, 8, 11, 13 days) has a strong anti-tumor growth effect[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic vascular injury mouse models[1]
Dosage: 18 nM CPG ODN
Administration: s.c, three times a week for 7 weeks
Result: Increased in aortic atherosclerotic plaque size compared to vehicle.
Animal Model: Lewis Lung Cancer Murine Tumor Model[3]
Dosage: 0.05 mg (1, 3, 5, 8, 11, 13 days)
Administration: Intraperitoneal injection (i.p.)
Result: Delayed tumor growth,decreased tumor weight and increased the apoptosis of tumor cells.
Molecular Weight

6364.10

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-C-G-T-T)
SMILES

[ODN 1826]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (7.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1571 mL 0.7857 mL 1.5713 mL
5 mM 0.0314 mL 0.1571 mL 0.3143 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.1571 mL 0.7857 mL 1.5713 mL 3.9283 mL
5 mM 0.0314 mL 0.1571 mL 0.3143 mL 0.7857 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ODN 1826 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 1826202668-42-6CpG 1826ODN1826ODN-1826CpG1826CpG-1826Toll-like Receptor (TLR)ApoptosisCPG ODNTLRAgonistAntitumorRAW 264.7Lewis Lung Cancer Murine Tumor ModelInhibitorinhibitorinhibit

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