ODN 24888

Cat. No.: HY-150744: FAQs
Data Sheet SDS Handling Instructions

Molarity Calculator

ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (ODN 24888 sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)

ODN 24888 Chemical Structure

CAS No. : 1964506-30-6

Size	Price	Stock
1 mg	USD 84	Ask For Quote & Lead Time
5 mg	USD 243	Ask For Quote & Lead Time
10 mg	USD 389	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of ODN 24888:

ODN 24888 sodium Get quote
ODN 24888 triethylamine Get quote

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•Related Small Molecules:

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View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms

TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TLR7

TLR9

Molecular Weight

4904.00

CAS No.

1964506-30-6

Appearance

Solid

Color

White to off-white

Sequence

DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)

SMILES

[DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Data Sheet (264 KB) SDS (251 KB) Handling Instructions (2659 KB)

References

[1]. Saul Meike, et al. Reduction of bone resorption, especially in chronic joint diseases: Germany, DE102019122014 A1. 2021-02-18.

[2]. Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated im mune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703. [Content Brief]

ODN 24888 Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 248881964506-30-6ODN24888ODN-24888Toll-like Receptor (TLR)guanine-modifiedINH-ODNIFN-αNF-κBIL6human peripheral blood mononuclear cellsPBMCsInhibitorinhibitorinhibit

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